Crews, a proud feminist and supporter of the #MeToo movement, recently explained why he did not fight back against the man he accused of sexually assaulting him.
In an emotional testimony before a US Senate committee, Crews testified in favour of proposed legislation known as the Sexual Assault Survivors Bill of Rights.
"The assault lasted only minutes, but what he was effectively telling me while he held my genitals in his hand, was that he held the power," he said in his opening statement. "That he was in control.
"This is how toxic masculinity permeates culture."
Asked by senator Dianne Feinstein why he, a "big powerful man", did not fight his alleged attacker off, he responded that his initial response was to become violent, but he held back.
While many people praised Crews for his moving testimony, rapper 50 Cent chose to mock the Brooklyn Nine-Nine star.
He posted a photo of Crews shirtless with the text: "I got raped / My wife just watched" and then another of Crews with a rose in his mouth which said "Gym time." He added the caption: "LOL what the f**k is going on out here man? Terry: I froze in fear... they would have had to take me to jail. Get the strap."
The comments section was instantly flooded with former fans and critics calling 50 out, branding him "disgusting" and observing: "This is why people hate you."
Asked for his thoughts on the comments by TMZ, Crews himself rose above it and simply said: "I love 50 Cent, I listen to his music when I'm working out."
Pressed to address his post mocking male sexual assault, Crews responded: "I prove that size doesn't matter when it comes to sexual assault."
50 Cent later deleted his post from Instagram.