Presenter Andrew Marr angrily accused Priti Patel of "laughing" at Brexit fears after the Home Secretary appeared to smirk during interview.
Marr chastised the Tory MP live on air as she tried to defend Boris Johnson's negotiations tactics with the EU.
The pair clashed as the BBC host listed industries who fear for their futures post-Brexit.
See the exchange in the above clip.
In other news, Jeremy Corbyn has signalled Labour is unlikely to back any Brexit deal struck by Boris Johnson, even if there was a confirmatory referendum.
On Saturday, shadow Brexit secretary Sir Keir Starmer said that if the Prime Minister returned from Brussels with an agreement Labour would demand it was put to the country in a confirmatory vote.
However, questioned on Sky News's Sophy Ridge on Sunday programme, Corbyn showed little enthusiasm for the idea.
"I think many in Parliament, not necessarily Labour MPs, others, might be more inclined to support it (if there was a referendum) even if they don't really agree with the deal. I would caution them on this," he said.
Mr Corbyn said there was now a "strong possibility" that there would be a general election before Christmas.
He said that it was "ludicrous" for the Government to be holding a Queen's Speech on Monday when it was more than 40 votes short of a Commons majority.
"It obviously depends on what happens this week, but we have a Government that is now in minus 40, it hasn't yet won a vote in Parliament," he said.
"Having a Queen's Speech and a State Opening of Parliament tomorrow is ludicrous. What we have got in effect is a party political broadcast from the steps of the throne."