His casting was first announced by Deadline, although it's not specified which real-life character he'll be portraying opposite Cillian Murphy's J. Robert Oppenheimer, father of the atomic bomb, .
On the big screen, Quaid was last spotted in Scream as Richie Kirsch.
For his theoretical physicist biopic, Oscar-nominated filmmaker Nolan has rounded up a true cast for the ages here.
Robert Downey Jr is onboard as the US Atomic Energy Commission's Lewis Strauss, Florence Pugh plays psychiatrist Jean Tatlock, Emily Blunt is Katherine Oppenheimer, Matt Damon is Manhattan Project director Leslie Groves Jr and Benny Safdie is the father of the hydrogen bomb, Edward Teller.
Dane DeHaan, Josh Hartnett and Rami Malek are all involved too.
As you'd expect, there's a particular buzz surrounding Oppenheimer, which Murphy himself contributed to earlier this month.
"It's the first time [Nolan's] cast me in a lead, which I'm still a bit in shock about, but I'm thrilled. It's a huge part and a lot of work. But in my estimation, you're working with one of the greatest living directors, so you're in safe hands."
The Peaky Blinders star continued: "The difference with this one is the story is there, everybody knows what happened. But Chris is telling it in a different way, as with Chris you would expect. That's all I can say.
"It does feel immense and it feels terrifying. But if I felt it was easy, I wouldn't be interested. I do get nervous, anxious and insecure, but then you go, 'F**k it. I have been doing it for 25 years and I have done it before. So just keep going.'"
Oppenheimer is slated to reach cinemas on July 23, 2023.
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