The fantasy action movie, which stars Dwayne 'The Rock' Johnson as a primatologist battling a variety of animals with super powers, took $34.5 million in its opening weekend to just about see off A Quiet Place.
John Krasinski's almost apocalyptical horror film, starring him alongside his wife Emily Blunt, took an impressive $32.6 million in its second weekend, according to Box Office Mojo's figures.
Nonetheless, it wasn't enough to topple Rampage, despite its critical panning.
In at a distant third was another new entry and horror film alike, in the shape of Truth or Dare.
The Blumhouse production, which stars Pretty Little Liars actress Lucy Hale as a college student whose friends find themselves in a life-threatening version of the popular game after a trip to Mexico, took £19.1 million in its opening weekend.
This was followed by Stephen Spielberg's virtual reality epic Ready Player One, which took $11.3 million this weekend.
Fifth place went to the John Cena/Ike Barinholtz/Leslie Mann comedy Blockers, which took $10.3 million, while the record-breaking Black Panther came in sixth place this week with $5.4 million.
Wes Anderson's animated adventure Isle of Dogs earned $5 million this weekend, placing it in seventh place.
In at eighth place is Christian rock drama I Can Only Imagine ($3.9 million), based on the song of the same name by MercyMe.
Tyler Perry's Acrimony took ninth position in this weekend's box office with £3.7 million, and Chappaquidick rounds off the top 10 with £3.1 million.
Until next week, folks.
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