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Coronavirus: The 12 major developments that happened on Wednesday

Here’s what you need to know on 22 July. This article was updated at 4.30pm.

Deaths: The government said 45,501 people had died in hospitals, care homes and the wider community after testing positive for coronavirus in the UK as of 5pm on Tuesday, up by 79 from the day before.

Scotland: Five businesses have been identified as being linked to an outbreak of coronavirus in a call centre in Lanarkshire. They include a Costa and three pubs. Read more here.

Science: A mutation of the COVID-19 disease is now the most dominant strand in the world, and clusters are forming more quickly in the UK than the original virus did in Wuhan, an expert has said. Professor Nick Loman, of the University of Birmingham, who is part of the COVID-19 Genomics Consortium, said the mutation, known as D614G, has an observable impact on cases in humans. Read more here.

Vaccines: Young people would be less likely to have a coronavirus vaccine if one were available, a new poll has found. According to a YouGov survey of 4,302 adults, 8% of those aged 18-24 said they would refuse a vaccine, compared with 13% in the 25-49 category. Read more here.

Thomas Lingelbach, chief executive of France-based drugs company Valneva, has said he does not believe a COVID-19 vaccine will be ready until mid-2021. He said: "Probability of success is always difficult to predict but I would really give the conventional approach that we are running right now a probability of success above 50%." Read more here.

Travel: The UK has not made the list of countries Irish people can visit without quarantining on return. The US and UK were left off the "green list" as only places that had the same or lower infection rate than Ireland were included. Read more here.

Read more about COVID-19

How to get a coronavirus test if you have symptoms

What you can and can’t do under lockdown rules

In pictures: How UK school classrooms could look in new normal

How public transport could look after lockdown

How our public spaces will change in the future

Rest of the world

Nearly 90% of people in the Australian state of Victoria with COVID-19 symptoms did not self-isolate, alarming new analysis has shown. According to 9 News, 3,400 of the 3,810 cases who made up the analysis carried on as normal, despite suffering symptoms of coronavirus. Read more here.

President Donald Trump has said the coronavirus situation will get worse in the US before it gets better. More than 140,000 Americans have died in just five months. Read more here.

A doctor in Ireland has died with COVID-19 after being in intensive care for three months. Dr Waqar Ali Shah was a frontline healthcare worker at Mater Misericordiae University Hospital. Read more here.

Brazilian president Jair Bolsonaro is still testing positive for COVID-19. The president first recorded a positive test on 7 July, but the government said he is in good health.

Positive news

People with family in care homes will be able to reunite after months, with the government set to allow visits again. The pandemic had stopped people going to see loved ones in care homes, to prevent spread to vulnerable people. Read more here.

Driving tests have resumed after a four-month suspension in England. Some 210,000 tests were cancelled and tens of thousands more were delayed because of the virus, but they can now resume, with face coverings and social distancing in place. Read more here.

Coronavirus: what happened today

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