In it, archaeology professor Indy returns for one last adventure in which he must track down an item known as the Dial of Destiny before his old nemeses the Nazis get to it first, and he goes on this mission with the help of his goddaughter Helena Shaw (Phoebe Waller-Bridge) and other familiar faces from his past.
The Disney flick is reported to have had a huge budget, though, which means it will need to make a significant amount at the box office to be considered a commercial success.
Here is everything that you need to know.
How much does Indiana Jones and the Dial of Destiny need to make to be profitable?
Indiana Jones and the Dial of Destiny is reported to have a budget of $295 million (£232 million) before marketing, which means that it needs to make at least three times that to be considered profitable: $750m to be exact.
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To be seen as a true success the film is said to need to earn $1 billion globally, but with Mission: Impossible - Dead Reckoning, Barbie and Oppenheimer competing for screens over the next few weeks, that seems to be a tall order.
Indiana Jones and the Dial of Destiny was projected to earn $145 million to $150 million worldwide, and in its opening weekend, per IMBb's Box Office Mojo, it earned $130 million. It is projected to go up to $152 million by the end of the July 4th weekend.
Domestically, Disney was said to be hoping the film would earn $65 million on its first day, but it ended up taking in $60 million upon debut.
While the film's earnings appear to be similar to what was predicted, the slight difference in numbers has had a big impact already because the blockbuster is seen to have done poorly.
According to The Hollywood Reporter, the audience demographic for the film skewed towards older viewers during its opening weekend as 42% of sales going to audience members who were aged 45 and up, with families and younger viewers having less of a turn out for the film.
For a franchise as massive as Indiana Jones, these numbers have come as quite a shock especially because of the enduring legacy of the franchise, which was previously helmed by Steven Spielberg.
It is not the only big budget blockbuster to currently be struggling at the box office, though, because The Flash has also not done as well as hoped.
Indiana Jones and the Dial of Destiny is out now in cinemas and IMAX. The Indiana Jones franchise is available to watch on Disney+.
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Watch: James Mangold and Harrison Ford discuss Indiana Jones and the Dial of Destiny.