After their high-flying form last season, Chris Wilder’s side have plummeted to the bottom of the table, taking just one point from their opening eight games.
The Blades invested heavily in striker Rhian Brewster, but they remain desperately short on goals, having scored just four so far all season.
READ MORE: Every Premier League fixture and table
Meanwhile, things are looking more optimistic for West Ham, who have 11 points despite a torrid run of fixtures. They have been without star forward Michail Antonio recently but the international break has aided his recovery.
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When is the match?
The game kicks off on Sunday 22 November at Bramall Lane.
What time is kick-off?
Kick-off is 2pm GMT.
How can I watch it?
The match is being broadcast on Sky Sports Main Event and Sky Sports Premier League. Subscribers can also stream the game live via the Sky Go app.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
READ MORE: West Ham losing £2m per match without fans
Sheffield United: Ramsdale, Basham, Egan, Ampadu, Baldock, Berge, Norwood, Fleck, Lowe, McBurnie, McGoldrick
West Ham: Fabianski, Balbuena, Ogbonna, Cresswell, Coufal, Rice, Soucek, Masuaku, Bowen, Fornals, Haller
What are the odds?
Sheffield United: 12/5
West Ham: 5/4
This weekend get a £10 free bet with Betfair, when you bet £10 on a Same Game Multi on the Premier League. Terms: Min £10 Same Game Multi bet on any EPL match this Fri - Sun. Free bet valid for 72 hours, awarded at bet settlement. Excludes cashed out bets. T&Cs apply.