Watch: Mickey Rourke criticises Tom Cruise's integrity as an actor
Rourke told Piers Morgan Uncensored: "That doesn't mean s*** to me. The guy's been doing the same effing part for 35 years. I got no respect for that."
"That’s the kind of actor I want to be like… Brando back in the day. The kind of guys who tried to stretch as actors.”
Asked if he thought Cruise was a good actor, he replied: “I think he's irrelevant, in my world.”
Rourke won the Best Actor Bafta and was nominated for an Oscar for his portrayal of an ageing wrestler in 2008 movie The Wrestler.
He said: "I am back in the wilderness after The Wrestler! But not really because what I learned to do, I wasn't gonna let anyone put me on the shelf because I've got enough ability and I've got more ability than most actors that are walking around, and if I could just behave myself, there's a lot of young up and coming directors that aren't afraid of how I used to be perceived.”
Rourke also opened up about meeting Russian President Vladimir Putin in 2014.
He said: "That was really heart-breaking to go to and I was talking to all these little kids... and I looked over at Vladimir and I could see somebody that was genuinely concerned about where we were and someone who was empathetic and he was there for a sincere reason.”
Rourke became emotional as he discussed the Russian invasion of Ukraine.
He said: “That’s the thing that blows my mind, because it's like two brother countries. And I don’t understand what he wants? Not only combatants are getting killed but old people are getting killed, young people are getting killed, schools are getting targeted, hospitals are getting targeted. All that is not right."
He went on: “I saw a guy, an image of a man who was looking at a hole, at a ditch, and he was looking for … I put myself in his position, he was looking for his brother and that kind of struck home with me and bothered me a lot.
"And made me think [Putin] he's doing really terrible, bad things and I wish some kind of little bell would ring in his head or his heart and he'd wake up and just stop all this."
Watch: Mickey Rourke on The Masked Singer