Campbell told fellow horror legend Jamie Lee Curtis in a chat for Variety that she was “really apprehensive” about doing another sequel following Craven’s death in 2015.
“I always felt like it’d be too difficult to do it without Wes,” she said. “He was the master of these films. He did such a beautiful job on them. We were a family.”
Ready Or Not directors Matt Bettinelli-Olpin and Tyler Gillett are set to walk in Craven’s footsteps for Scream 5 and Campbell revealed they wrote her a letter affirming their respect for the filmmaker.
Watch: Campbell and Curtis discuss their horror legacies
“They said they basically are directors because of these films,” she said.
The 47-year-old added: “They’re really so excited to be a part of these films and what an honour it is to do them, and that they really want to do justice to Wes and honour his legacy.”
Campbell said the letter “meant a lot” to her and that she was happy to work with directors who were “doing it for the love of these films”.
Nightmare on Elm Street creator Craven directed all four of the previous Scream movies, with 2011 outing Scream 4 serving as the final film he made before his passing.
Campbell will reprise the role of “final girl” Sidney Prescott for Scream 5 and will be joined by her long-time co-stars Courteney Cox as Gale Weathers and David Arquette as Dewey Riley.
As well as the three big screen sequels, a TV series loosely based on the franchise has run for three seasons since 2015.
This new movie, however, will be the first time the central cast has appeared together since Craven passed away.
Bettinelli-Olpin and Gillett scored a major genre hit last year with Ready or Not, which raked in $58m (£44.3m) worldwide from a budget of just $6m (£4.6m).
Scream 5 is due to be released into cinemas in January 2022.
Watch: Neve Campbell confirms Scream return